Never built variants in italics.
| 727-100 | Basic Model | Passenger Service |
| 727-100C | Convertible | Cargo door on left side of front fuse. Passenger/cargo or mixed load possible. Reconfiguration in about two hours. |
| 727-100QC | Quick Change | Same as 727C but with palletized interior fittings, allowing reconfiguration in less than 30 minutes. |
| 727-100M | Military | Military version of the 727C with possible roles as Assault, staff and command transport, tanker, medevac and carrier onboard delivery(!) |
| 727-100VIP | VIP | Executive jet variant |
| 727-200 | Stretch | Passenger Service. Stretched by 20 feet. |
| 727BJ | Business Jet | Not an official designation, but widely used. Can refer to both the -100 and the -200 |
| Advanced 727-200 | Advanced model | Increased take off weight. Higher thrust engines. 50% greater range. Lower noise signature, This was the standard version after 1972. |
| 727-200F | Freighter | Pure freighter version. |
| 727UDF | UnDucted Fan | Not an official designation. Test bed for the GE UDF programme |
| 727-300 | Further Stretch | 220 inch stretch of the -200 for passenger service with modified wing, bogie main gear and wide fan engines. Cancelled in favor of the 757. |
| 727-100QF | Quiet Freighter | Not an official designation. UPS reengined variant of the -100. |